Tirzepatide dosing, step by step
- Maintenance for weight reduction: 5, 10 or 15 mg weekly.
- Step size: 2.5 mg, after at least 4 weeks on the current dose.
At Rxely, dose changes go through your clinician at online check-ins.
Tirzepatide dosing for weight loss in units
Units measure syringe volume, not dose. On a U-100 syringe, 100 units equal 1 mL, so units = (mg dose divided by vial mg per mL) times 100. Your vial label gives the concentration.
Example only, at 10 mg/mL:
| Dose | Volume | Units (U-100) |
|---|---|---|
| 2.5 mg | 0.25 mL | 25 units |
| 5 mg | 0.50 mL | 50 units |
| 7.5 mg | 0.75 mL | 75 units |
| 10 mg | 1.00 mL | 100 units |
Different concentration, different units. Every Rxely order includes written dosing instructions.
Where to inject tirzepatide
Belly, thigh, or the back of the upper arm when someone else gives it. Rotate sites every week. Any time of day works, with or without meals (label, section 2.4).
Microdosing tirzepatide
The label has no microdose step. Its lowest dose is 2.5 mg. Anything outside the chart is your clinician's call.
What each step costs
Brand self-pay totals $1,197 over the first three steps. Three months at our $89 start is $267. Full math: Zepbound cost vs. compounded tirzepatide.
Keep reading
Sources
- Eli Lilly. Zepbound (tirzepatide) prescribing information, Revised 08/2026, sections 2.1, 2.2 and 2.4. pi.lilly.com/us/zepbound-uspi.pdf. Accessed November 1, 2026.
- Eli Lilly. Zepbound coverage and savings. zepbound.lilly.com/coverage-savings. Accessed November 1, 2026.
- Rxely pricing: rxely.com/#pricing.